January 2025 - Exceptional Quantitative Performance of NeuroEXPLORER Brain PET Scanner

2025-Negar-Omidvari

Assistant Project Scientist Negar Omidvari and her colleagues have demonstrated the high quantitative precision and accuracy of the NeuroEXPLORER, a next-generation dedicated brain PET system. The paper, now available in the Journal of Nuclear Medicine, presents extensive evaluations using phantom and human data across a broad range of imaging conditions relevant to dynamic neuroimaging.

The NeuroEXPLORER’s extended axial field of view, combined with its high spatial resolution and sensitivity, was shown to deliver consistent quantitative performance—even with low activity levels and short frame durations. Key findings include less than 5% bias across a wide activity range and sub-1% variations in r covery coefficients, confirming the scanner’s suitability for high-resolution dynamic brain studies.

These results underscore the NeuroEXPLORER’s potential to advance research in neurological disorders by enabling more precise, flexible, and sensitive molecular imaging.

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